Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

• Published in: Journal of clinical and diagnostic research Vol. 8; no. 9; pp. ZC91 - ZC94
• Main Authors: Basnaker, Maharudrappa, Sr, Shashikanth, Bnvs, Satish
• Format: Journal Article
• Language: English
• Published: India JCDR Research and Publications (P) Limited 01-09-2014; JCDR Research and Publications Private Limited
• Subjects: angiogenisis; Dentistry; endoglin cd 105; microvessel density; oral dysplasia; oral squamous cell carcinoma; tobacco chewers; Endoglin CD 105; Oral dysplasia; Oral squamous cell carcinoma; Microvessel density; Tobacco chewers; Angiogenisis
• ISSN: 2249-782X; 0973-709X
• DOI: 10.7860/JCDR/2014/9429.4904

To assess the expression of Endoglin (CD-105) and Microvessel Density in clinically normal oral mucosa of non-tobacco and tobacco habituated patients & also histopathologically confirmed cases of oral squamous cell carcinoma (OSCC) patients.
Twenty cases of clinically normal oral mucosa with tobacco habituation in the form of chewing or smoking, 20 histopathologically confirmed cases of OSCC and twelve normal healthy oral mucosal cases without tobacco habituation in any form, served as control group, were immunohistochemically analysed for expression of Endoglin (CD-105). Chi-square test is used to determine statistical analysis and significance.
The finding of 65% of Endoglin CD - 105 positivity and microvessel density (MVD) in the mucosal specimens of tobacco users may be attributed as neoangiogenesis or angiogenic squamous dysplasia like phenomenon occurring as important pathological biomarker preceding oral cancer development, and may therefore be useful as a predictive marker of malignancy.