Soluble CD146 and APS: a potential biomarker of obstetrical complications?

Obstetric antiphospholipid syndrome (APS) seems to be a clinical subset of classical APS, for which the search for new markers is still challenging. Soluble CD146 (sCD146) constitutes a circulating endothelial biomarker. sCD146 is involved in the inflammatory response by promoting monocyte transmigr...

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Bibliographic Details
Published in:	Lupus Vol. 21; no. 7; pp. 779 - 780
Main Authors:	Kaspi, E, Chabaud, MB, George, FD, Bardin, N
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-06-2012 Sage Publications Ltd
Subjects:	Abortion Age Angiogenesis antiphospholipid syndrome Antiphospholipid Syndrome - blood Biomarkers Biomarkers - blood CD146 Antigen - blood Cell migration Endothelial cells Female Fetuses Humans Inflammation Ischemia Lupus Monocytes Obstetrics Physiology Preeclampsia Pregnancy Pregnancy Complications - blood Sex Vein & artery diseases Womens health France Pregnancy soluble CD146 Antiphospholipid Syndrome
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Summary:	Obstetric antiphospholipid syndrome (APS) seems to be a clinical subset of classical APS, for which the search for new markers is still challenging. Soluble CD146 (sCD146) constitutes a circulating endothelial biomarker. sCD146 is involved in the inflammatory response by promoting monocyte transmigration and displays chemotactic and angiogenic properties on endothelial cells. Its detection in human sera reveals physiological variations related to age and sex. A wide variation of sCD146 has been reported in several conditions. In particular, sCD146 levels are significantly higher in women presenting a history of recurrent fetal losses.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203312436864