A “Switch” in Time through Genes Aligned: Unraveling the Genomic Landscape of HSC Development

A “Switch” in Time through Genes Aligned: Unraveling the Genomic Landscape of HSC Development

Seeking to define the “switch” from fetal to adult hematopoiesis, Li et al. (2020) performed extensive genomic and epigenomic profiling of hematopoietic stem and progenitor cells across ontogeny (as explored in this issue of Cell Stem Cell). Gradual and stochastic changes in genomic and epigenomic r...

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Bibliographic Details
Published in:Cell stem cell Vol. 27; no. 5; pp. 695 - 697
Main Authors: Apostol, April C., López, Diego A., Beaudin, Anna E.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 05-11-2020
Subjects:
Epigenomics
Fetus
Hematopoiesis - genetics
Hematopoietic Stem Cells
Single-Cell Analysis
Online Access:Get full text
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Summary:Seeking to define the “switch” from fetal to adult hematopoiesis, Li et al. (2020) performed extensive genomic and epigenomic profiling of hematopoietic stem and progenitor cells across ontogeny (as explored in this issue of Cell Stem Cell). Gradual and stochastic changes in genomic and epigenomic regulation suggest the absence of any specific regulator. Seeking to define the “switch” from fetal to adult hematopoiesis, Li et al. (2020) performed extensive genomic and epigenomic profiling of hematopoietic stem and progenitor cells across ontogeny (as explored in this issue of Cell Stem Cell). Gradual and stochastic changes in genomic and epigenomic regulation suggest the absence of any specific regulator.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Commentary-1
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2020.10.011