Visualisation of enantiomers via insertion of a BIRD module in X–H correlation experiments in chiral liquid crystal solvent

• Published in: Journal of magnetic resonance (1997) Vol. 183; no. 1; pp. 60 - 67
• Main Authors: Ziani, L., Courtieu, J., Merlet, D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-11-2006
• Subjects: Algorithms; BIRD; Chiral discrimination; Chiral liquid crystal; Heteronuclear 2D NMR; Isomerism; Liquid Crystals - analysis; Liquid Crystals - chemistry; NMR in oriented media; Nuclear Magnetic Resonance, Biomolecular - methods; Residual dipolar coupling; Solvents - chemistry; Statistics as Topic; Residual dipolar coupling; Chiral liquid crystal; NMR in oriented media; Heteronuclear 2D NMR; BIRD; Chiral discrimination
• ISSN: 1090-7807; 1096-0856
• DOI: 10.1016/j.jmr.2006.07.011

Several
13C–
1H NMR techniques are derived simplifying the visualisation of enantiomers in chiral ordering solvents. They proceed through various heteronuclear 2D experiments where a bilinear rotation decoupling sequence (BIRD) is inserted in the middle of the
t
1 evolution period. In this way, the small couplings are refocused while the large couplings are preserved. The methods allow extracting precise values of one-bond carbon-proton residual dipolar couplings for each enantiomer out of unresolved proton-coupled
13C or carbon-coupled
1H spectra. Illustrative examples are analysed and discussed using various pulse sequences.