Polymorphisms of the lipoprotein lipase gene as genetic markers for stroke in colombian population: a case control study

• Published in: Colombia medica (Cali, Colombia) Vol. 47; no. 4; pp. 189 - 195
• Main Authors: Velásquez Pereira, Leydi Carolina, Vargas Castellanos, Clara Inés, Silva Sieger, Federico Arturo
• Format: Journal Article
• Language: English
• Published: Colombia Universidad del Valle 30-12-2016
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Brain Ischemia - genetics; Case-Control Studies; Colombia; Female; Genetic Markers; Genotype; Humans; Lipoprotein Lipase - genetics; Male; Middle Aged; Original; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Stroke - genetics; Colombia; Lipoprotein Lipase; Myocardial Infarction; Coronary Disease; Polymorphism Single Nucleotide; Genotype; Risk; Polymorphism Genetic
• ISSN: 0120-8322; 1657-9534
• DOI: 10.25100/CM.V47I4.1683

To analyze if there is an association between the presence of polymorphisms in the
gene (rs320, rs285 and rs328) with development of acute ischemic stroke in Colombian population.
In a case control design, 133 acute ischemic stroke patients (clinical diagnosis and x-ray CT) and 269 subjects without stroke as controls were studied. PCR -RFLP technique was used to detect rs320, rs285 and rs328 polymorphisms in the LPL gene.
In the present research was not found any association between any of the LPL gene polymorphism and acute ischemic stroke in the population studied; the allele and genotypic frequencies of the studied polymorphisms were similar in cases and controls and followed the Hardy-Weinberg equilibrium. The study was approved by the IRB and each subject signed the informed consent.
LPL gene polymorphisms are not genetic markers for the development of stroke in the Colombian sample used.