Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine

1. This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pha...

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Bibliographic Details
Published in:	Cellular and molecular neurobiology Vol. 19; no. 4; pp. 427 - 442
Main Authors:	Rotzinger, S, Bourin, M, Akimoto, Y, Coutts, R T, Baker, G B
Format:	Journal Article
Language:	English
Published:	United States 01-08-1999
Subjects:	Animals Antidepressive Agents - metabolism Antidepressive Agents - pharmacokinetics Antidepressive Agents, Second-Generation - metabolism Antidepressive Agents, Second-Generation - pharmacokinetics Clinical Trials as Topic Drug Interactions - physiology Humans
Online Access:	Get full text
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Summary:	1. This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pharmacokinetic drug-drug interactions, particularly as they relate to cytochrome P450 enzymes, are provided.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0272-4340
DOI:	10.1023/a:1006953923305