Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food...

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Bibliographic Details
Published in:	Trends in parasitology Vol. 38; no. 8; pp. 614 - 617
Main Authors:	Tandoh, Kwesi Z., Morang'a, Collins M., Wilson, Michael, Quashie, Neils B., Duah-Quashie, Nancy O.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2022
Subjects:	artemisinin resistance extracellular vesicles hypothetical model artemisinin resistance hypothetical model extracellular vesicles
Online Access:	Get full text
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Summary:	Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-4922 1471-5007
DOI:	10.1016/j.pt.2022.05.004