Molecular Imprinting: Green Perspectives and Strategies

• Published in: Advanced materials (Weinheim) Vol. 33; no. 30; pp. e2100543 - n/a
• Main Authors: Arabi, Maryam, Ostovan, Abbas, Li, Jinhua, Wang, Xiaoyan, Zhang, Zhiyang, Choo, Jaebum, Chen, Lingxin
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01-07-2021
• Subjects: Antibodies; Antigens; green chemistry; GREENIFICATION strategy; Molecular imprinting; molecularly imprinted polymers; Substrates; Sustainable development; Waste treatment
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.202100543

Advances in revolutionary technologies pose new challenges for human life; in response to them, global responsibility is pushing modern technologies toward greener pathways. Molecular imprinting technology (MIT) is a multidisciplinary mimic technology simulating the specific binding principle of enzymes to substrates or antigens to antibodies; along with its rapid progress and wide applications, MIT faces the challenge of complying with green sustainable development requirements. With the identification of environmental risks associated with unsustainable MIT, a new aspect of MIT, termed green MIT, has emerged and developed. However, so far, no clear definition has been provided to appraise green MIT. Herein, the implementation process of green chemistry in MIT is demonstrated and a mnemonic device in the form of an acronym, GREENIFICATION, is proposed to present the green MIT principles. The entire greenificated imprinting process is surveyed, including element choice, polymerization implementation, energy input, imprinting strategies, waste treatment, and recovery, as well as the impacts of these processes on operator health and the environment. Moreover, assistance of upgraded instrumentation in deploying greener goals is considered. Finally, future perspectives are presented to provide a more complete picture of the greenificated MIT road map and to pave the way for further development.
Due to increasing concerns about the detrimental impacts of unsustainable molecular imprinting technology (MIT), MIT has veered toward greener pathways. Fourteen green principles specifically for MIT are codified using a nomenclature of “GREENIFICATION.” All aspects of greenificated MITs, including fundamentals, strategies, and future perspectives, are comprehensively reviewed. Moreover, a roadmap of greenificated MIT from 2012 to 2030 is proposed.