Autoregulation of zonal glomerular filtration rate and renal blood flow in spontaneously hypertensive rats

• Published in: The American journal of physiology Vol. 269; no. 4 Pt 2; pp. F515 - F521
• Main Authors: Wang, X, Aukland, K, Ofstad, J, Iversen, B M
• Format: Journal Article
• Language: English
• Published: United States 01-10-1995
• Subjects: Animals; Aprotinin - blood; Aprotinin - pharmacokinetics; Glomerular Filtration Rate; Hemodynamics; Homeostasis; Hypertension - physiopathology; Iodine Radioisotopes; Kidney - pathology; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation
• ISSN: 0002-9513
• DOI: 10.1152/ajprenal.1995.269.4.F515

Autoregulation of total and zonal glomerular filtration rate (GFR) in outer, middle and inner cortex was estimated in spontaneously hypertensive rats (SHR), from the tubular uptake of 125I-labeled aprotinin (125I-Ap), injected at control renal arterial pressure (RAP), and 131I-Ap, injected at reduced RAP in left kidney. Normotensive Wistar-Kyoto (WKY) rats were used as controls. Renal blood flow (RBF) autoregulation was reset to higher pressure levels in SHR. When RAP was lowered close to the lower pressure limit of RBF autoregulation, total GFR was reduced to 89.5 +/- 3.1 and 88.1 +/- 3.3% of control in 10- and 40-wk WKY and to 87.7 +/- 2.3 and 88.0 +/- 2.2% in 10- and 40-wk SHR. In WKY, the fall of GFR in the three cortical layers was not different during RAP reduction. In 10- and 40-wk-old SHR, however, GFR fell significantly less in inner than in middle and outer cortex (P < 0.05). We conclude that autoregulation of GFR is most efficient in the inner cortex of SHR. In all animals, GFR was less well autoregulated than RBF.