Physical evidence on desmin–lamin B interaction

• Published in: Cytoskeleton (Hoboken, N.J.) Vol. 78; no. 1; pp. 14 - 17
• Main Authors: Kural‐Mangıt, Ecem, Dinçer, Pervin Rukiye
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01-01-2021; Wiley Subscription Services, Inc
• Subjects: Cytoplasm; Danio rerio; Desmin; Immunoprecipitation; lamin B; muscle; zebrafish; desmin; zebrafish; immunoprecipitation; lamin B; muscle
• ISSN: 1949-3584; 1949-3592
• DOI: 10.1002/cm.21651

Desmin is a muscle specific intermediate filament protein located in cytoplasm. Lamin B, on the other hand, is a nuclear intermediate filament protein. There are studies suggesting a possible interaction between desmin and lamin B yet there is no physical evidence. In the present study, we have shown for the first time a physical interaction between desmin and lamin B via reciprocal co‐immunoprecipitation from muscle tissue of wild type AB zebrafish (Danio rerio, Hamilton). The interaction between desmin and lamin B might be a lead on a novel nucleocytoplasmic communication network.