Diagnostic accuracy of cytology and urine methylation test in patients with non-muscle invasive bladder cancer: a systematic review and meta-analysis

Diagnostic accuracy of cytology and urine methylation test in patients with non-muscle invasive bladder cancer: a systematic review and meta-analysis

Multiple clinical studies have demonstrated the numerous advantages of urine methylation test over cytology for monitoring patients with non-muscle invasive bladder cancer (NMIBC) following surgery. This research aims to provide a systematic review and meta-analysis to evaluate the efficacy and limi...

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Bibliographic Details
Published in:Frontiers in oncology Vol. 14; p. 1412346
Main Authors: Yao, Zhuoyue, Wang, Tao, Liu, Jingpeng, Zhou, Zhongbao, Zhang, Yong
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 03-09-2024
Subjects:
diagnose
meta-analysis
NMIBC
Oncology
receiver operating characteristic
urine methylation test
urine methylation test
meta-analysis
NMIBC
receiver operating characteristic
diagnose
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Summary:Multiple clinical studies have demonstrated the numerous advantages of urine methylation test over cytology for monitoring patients with non-muscle invasive bladder cancer (NMIBC) following surgery. This research aims to provide a systematic review and meta-analysis to evaluate the efficacy and limits of urine methylation test in the clinical management of NMIBC. This research was carried out by conducting a comprehensive search of clinical trials comparing cytology and urine methylation test for NMIBC follow-up using databases such as PubMed, Embase, Web of Science, and the Cochrane Library up until May 2023, including references from relevant articles. The study is registered on PROSPERO with ID CRD42023398969. This study comprised six studies with a total of 1676 patients. The analysis revealed that the AUC of urine methylation test had a greater AUC than that of the cytology examination (0.89 vs 0.71). In post-operative follow-up of patients with NMIBC, the urine methylation test demonstrated a significant sensitivity (0.69 vs 0.52), but with lower specificity (0.87 vs 0.93) than cytology examination. The urine methylation test and cytology examination have both shown strong diagnostic performance in screening for NMIBC patients. However, urine methylation test outperforms cytology examination in terms of accuracy and sensitivity. PROSPERO, identifier CRD42023398969.
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Roberto Contieri, Humanitas University, Italy
Edited by: Badrinath Konety, Allina Health, United States
Vincenzo Fiorentino, University of Messina, Italy
Reviewed by: Maurizio Martini, University of Messina, Italy
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1412346