Glutathione as the End Capper for Cyclodextrin/PEG Polyrotaxanes

A facile one-pot synthesis of α-cyclodextrin-based polyrotaxane （PR） in aqueous solution is reported, where the peptide glutathione was used as the end-capping agent and the thiol-ene Michael addition was used as the end-capping reaction. Both polyrotaxanes with low threading ratio and high threadin...

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Bibliographic Details
Published in:	Chinese journal of polymer science Vol. 32; no. 8; pp. 1003 - 1009
Main Authors:	Song, Qiao, Luo, Zhi, Tong, Xinming, Du, Yi, Huang, Yanbin
Format:	Journal Article
Language:	English
Published:	Heidelberg Chinese Chemical Society and Institute of Chemistry, CAS 01-08-2014
Subjects:	Aqueous solutions Biocompatibility Biomaterials Biomedical materials Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Condensed Matter Physics Glutathione Industrial Chemistry/Chemical Engineering Polymer Sciences Reagents Surgical implants Synthesis 一锅合成封盖机环糊精生物相容性聚乙二醇谷胱甘肽轮烷迈克尔加成 Biocompatibility Cyclodextrin Polyrotaxane Polyethylene glycol Glutathione
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Summary:	A facile one-pot synthesis of α-cyclodextrin-based polyrotaxane （PR） in aqueous solution is reported, where the peptide glutathione was used as the end-capping agent and the thiol-ene Michael addition was used as the end-capping reaction. Both polyrotaxanes with low threading ratio and high threading ratio were successfully obtained. In contrast to the conventionally used multiple-step synthesis methods and hydrophobic end cappers, this one-pot aqueous synthesis as well as the biocompatibility of the end-capping agent could result in a much more biocompatible PR to be used as biomaterials.
Bibliography:	A facile one-pot synthesis of α-cyclodextrin-based polyrotaxane （PR） in aqueous solution is reported, where the peptide glutathione was used as the end-capping agent and the thiol-ene Michael addition was used as the end-capping reaction. Both polyrotaxanes with low threading ratio and high threading ratio were successfully obtained. In contrast to the conventionally used multiple-step synthesis methods and hydrophobic end cappers, this one-pot aqueous synthesis as well as the biocompatibility of the end-capping agent could result in a much more biocompatible PR to be used as biomaterials. Polyrotaxane; Cyclodextrin; Polyethylene glycol; Glutathione; Biocompatibility. 11-2015/O6 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0256-7679 1439-6203
DOI:	10.1007/s10118-014-1477-y