Calcium-channel blockers and anaesthesia

Verapamil was the first calcium-channel blocker (CCB). It has been used since 1962 in Europe then in Japan for its antiarrhythmic and coronary vasodilator effects. The CCB have become prominent cardiovascular drugs during the last 15 years. Many experimental and clinical studies have defined their m...

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Bibliographic Details
Published in:	Canadian journal of anesthesia Vol. 38; no. 1; pp. 75 - 89
Main Authors:	DURAND, P.-G, LEHOT, J.-J, FOEÊX, P
Format:	Journal Article
Language:	English
Published:	Toronto, ON Canadian Anesthesiologists' Society 1991
Subjects:	Anesthetics - pharmacology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Calcium Channel Blockers - classification Calcium Channel Blockers - pharmacology Drug Interactions Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Anesthetic Surgery Calcium antagonist Anesthesia Drug interaction Review Mechanism of action
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Summary:	Verapamil was the first calcium-channel blocker (CCB). It has been used since 1962 in Europe then in Japan for its antiarrhythmic and coronary vasodilator effects. The CCB have become prominent cardiovascular drugs during the last 15 years. Many experimental and clinical studies have defined their mechanism of action, the effects of new drugs in this therapeutic class, and their indications and interactions with other drugs. Due to the large number of patients treated with CCB it is important for the anaesthetist to know the general and specific problems involved during the perioperative period, the interactions with anaesthetics and the practical use of these drugs.
ISSN:	0832-610X 1496-8975
DOI:	10.1007/BF03009168