The roles of liver sinusoidal endothelial cells in liver ischemia/reperfusion injury

• Published in: Journal of gastroenterology and hepatology Vol. 39; no. 2; pp. 224 - 230
• Main Authors: Yinzhi, Deng, Jianhua, He, Hesheng, Luo
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01-02-2024
• Subjects: Autophagy; Endothelial cells; Hepatectomy; Hepatocytes; Hypoxia; Inflammation; Ischemia; Ischemia/reperfusion injury; Liver; Liver diseases; Liver sinusoidal endothelial cells; Liver transplantation; Reperfusion; Sterile inflammatory response; Therapeutic targets; Liver sinusoidal endothelial cells; Ischemia/reperfusion injury; Sterile inflammatory response; Liver
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.16396

Liver ischemia/reperfusion injury (IRI) is a major complication after partial hepatectomy and liver transplantation and during hypovolemic shock and hypoxia‐related diseases. Liver IRI is a current research hotspot. The early stage of liver IRI is characterized by injury and dysfunction of liver sinusoidal endothelial cells (LSECs), which, along with hepatocytes, are the major cells involved in liver injury. In this review, we elaborate on the roles played by LSECs in liver IRI, including the pathological features of LSECs, LSECs exacerbation of the sterile inflammatory response, LSECs interactions with platelets and the promotion of liver regeneration, and the activation of LSECs autophagy. In addition, we discuss the study of LSECs as therapeutic targets for the treatment of liver IRI and the existing problems when applying LSECs in liver IRI research.