Decreased plasma adiponectin concentrations in patients with syndrome X

• Published in: Acta Cardiologica Vol. 65; no. 2; pp. 217 - 220
• Main Authors: Susam, Ibrahim, Yaylali, Yalin Tolga, Dursunoğlu, Dursun, Göksoy, Hidayet, Öztürk, Mehmet, Yaylali, Olga, Semiz, Ender
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01-04-2010
• Subjects: Adiponectin; Adiponectin - blood; Adult; Aged; Algorithms; Angina Pectoris - blood; Angina Pectoris - diagnosis; Angina Pectoris - physiopathology; Biomarkers - blood; Body Mass Index; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; Case-Control Studies; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Coronary Angiography; coronary artery disease; coronary risk; Endothelium, Vascular - physiopathology; Exercise Test; Female; Humans; Male; Metabolic Syndrome - blood; Metabolic Syndrome - diagnosis; Metabolic Syndrome - physiopathology; Middle Aged; Risk Factors; syndrome X; Tomography, Emission-Computed, Single-Photon; Triglycerides - blood
• ISSN: 0001-5385; 1784-973X; 0001-5385
• DOI: 10.2143/AC.65.2.2047056

Objective - The levels of adiponectin, an anti-atherogenic protein, are decreased in patients with coronary artery disease. Syndrome X is associated with endothelial dysfunction, which is a key feature in the evolution of atherosclerosis.We sought to determine whether serum adiponectin levels are decreased in patients with syndrome X.
Methods - Twenty-three syndrome X patients (14 men, 9 women) who presented with stable angina pectoris, had a positive non-invasive stress test or an abnormal myocardial perfusion scintigraphy single photon emission computed tomography (MPS SPECT) and a normal coronary angiogram, were included in our study, as were 17 asymptomatic healthy subjects (13 men, 4 women) with normal results from non-invasive stress testing. The serum adiponectin levels and lipid profiles of the patients and control subjects were determined with venous samples collected after a 12-hour fast. The results were analysed by a Mann Whitney U test.
Results - Mean age (54.1 ± 11.8 y in patients and 59.8 ± 9.6 y in control subjects, P > 0.05) and body mass index (28.0 ± 3.3 in patients and 27.1 ± 4.2 in control subjects, P > 0.05) did not differ between the two groups. Adiponectin levels in patients with syndrome X (1.5 ± 1.1 mg/dl) were significantly lower than those in the control group (5.3 ± 2.9 mg/dl, P < 0.0001). Serum total cholesterol (TCHOL), triglyceride (TG), LDL, and HDL-cholesterol levels did not differ between the two groups (P > 0.05).
Conclusion - Serum adiponectin levels were lower in patients with syndrome X, and these low adiponectin concentrations may cause endothelial dysfunction.Thus, patients with a marked drop in adiponectin levels may be considered at high risk for future coronary events and may therefore benefit from additional pharmacological treatment.