Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages

X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In a...

Full description

Saved in:

Bibliographic Details
Published in:	Human genetics Vol. 52; no. 1; pp. 127 - 132
Main Authors:	Natarajan, A T, Meyers, M
Format:	Journal Article
Language:	English
Published:	Germany 01-11-1979
Subjects:	Ataxia Telangiectasia - genetics Cell Cycle Cells, Cultured Chromatids - radiation effects Chromosome Aberrations Chromosomes, Human - radiation effects Fibroblasts - radiation effects Humans Lymphocytes - radiation effects Thymidine Tritium X-Rays
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles-namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In addition, AT cells were sensitive to induction of chromosomal aberrations by tritium beta rays from incorporated radioactive thymidine. Possible reasons for the increased sensitivity of AT cells for induction of chromosomal aberrations by ionizing radiations are discussed.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0340-6717 1432-1203
DOI:	10.1007/bf00284606