Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect

Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect

The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin...

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Bibliographic Details
Published in:Cell metabolism Vol. 25; no. 4; pp. 757 - 758
Main Authors: Habener, Joel F, Stanojevic, Violeta
Format: Journal Article
Language:English
Published: United States 04-04-2017
Subjects:
Animals
Glucagon
Glucagon-Like Peptide 1
Incretins
Insulin
Mice
Pancreas
Peptide Fragments
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Summary:The gut is believed to be the source of GLP-1 that augments insulin secretion in response to oral nutrients. In this issue of Cell Metabolism, Chambers et al. (2017) shift the paradigm by finding that GLP-1 produced within the islets of the pancreas, and not the gut, is responsible for the incretin effect in mice.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2017.03.020