Comparison of Patients' Ethical Perspectives of Preimplantation Embryo Genetic Testing for Aneuploidy (PGT-A) vs. Monogenic Disorders (PGT-M)

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Vol. 28; no. 11; p. 3272
• Main Authors: Zhang, J, Rubin, L R, Zierhut, H, Pastore, L M
• Format: Journal Article
• Language: English
• Published: United States 01-11-2021
• Subjects: Adult; Aneuploidy; Blastocyst - physiology; Decision Making - ethics; Female; Genetic Testing - ethics; Genetic Testing - methods; Humans; Middle Aged; Pregnancy; Preimplantation Diagnosis - ethics; Preimplantation Diagnosis - methods; Young Adult; Attitudes; Preimplantation genetic testing; Aneuploidy; Monogenic disorders; Ethics or ethical issues
• ISSN: 1933-7205
• DOI: 10.1007/s43032-021-00644-w

What are the ethical perspectives of preimplantation genetic testing in patients using/considering PGT-A compared to those using/considering PGT-M? A 17-item questionnaire administered online was used to assess ethical perspectives in US patients who recently used/considered PGT-A (n=80) vs. those who used/considered PGT-M (n=72). Kruskal-Wallis, Chi-square, and Fisher exact tests were conducted with STATA. Most PGT-A and PGT-M users/considerers supported using PGT to screen for diseases fatal in childhood (86-89%) and those causing lifelong disabilities (76-79%) and opposed using PGT to screen for non-medical physical (80-87%) or intellectual traits (74-86%). Both groups agreed that PGT aids in parental decision-making, although some expressed concern over its potential to lead to unforeseen consequences for society and the PGT offspring. More PGT-M than PGT-A users/considerers opposed implanting genetically abnormal embryos when requested by parents (29% PGT-A vs. 56% PGT-M, p = 0.007). For embryo disposition, more PGT-A users/considerers favored freezing (95% PGTA vs. 82% PGT-M, p = 0.018) or donating genetically normal embryos to research (73% PGT-A vs. 57% PGT-M, p = 0.044), while more PGT-M users/considerers supported donating embryos with known genetic abnormalities to research (56% PGT-A vs. 81% PGT-M, p = 0.001). Regardless of the reason for using PGT, users generally agreed on the acceptable and unacceptable uses for it, as well as the potential societal impact. PGT-M users/considerers expressed more opposition than PGT-A users/considerers to implanting embryos with a genetic alteration when requested by the parents.