Efficacy and Safety of Combined Oral Chelation with Deferiprone and Deferasirox on Iron Overload in Transfusion Dependent Children with Thalassemia – A Prospective Observational Study

• Published in: Indian journal of pediatrics Vol. 88; no. 4; pp. 330 - 335
• Main Authors: DivakarJose, Rajeswari Rethinaswamy, Delhikumar, C. G., Ram Kumar, G.
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01-04-2021
• Subjects: Gynecology; Medicine; Medicine & Public Health; Original Article; Pediatrics; Deferasirox; Thalassemia; Deferiprone; Cardiac iron overload; Children; Dual oral chelation
• ISSN: 0019-5456; 0973-7693
• DOI: 10.1007/s12098-020-03442-5

Objectives
To assess the efficacy and safety of dual oral iron chelation therapy (deferiprone and deferasirox) in decreasing iron overload status, using serum ferritin and liver and cardiac MRI as indicators, in transfusion dependent thalassemic children.
Methods
This was a prospective observational study conducted in a tertiary care hospital for a period of one year. Children with thalassemia between 2 and 18 y of age with serum ferritin above 1500 ng/ml were started on oral deferiprone and deferasirox. They were followed up for one year. Serum ferritin and MRI quantification of liver and cardiac iron concentration was done at enrolment and end of 12 mo. They were also monitored monthly for any adverse effects.
Results
Twenty one thalassemic children with mean age of 7.8 y (range 4–12 y) and a mean ferritin value of 3129 + 1231.5 ng/ml were enrolled. Mean serum ferritin decreased by 1226.3 ng/ml (
p
 = 0.047, 95% CI =10.2, 1504.3) with 16.8% fall from baseline. The reduction in ferritin correlated significantly with the initial ferritin level (spearman’s rho = 0.742,
p
 = 0.001). Mean liver iron concentration and myocardial iron concentration did not change significantly. Red color urine, transient rise in creatinine and liver enzymes were noted during the study period.
Conclusions
Combined oral chelation with deferiprone and deferasirox significantly decreases the serum ferritin level in children with severe iron overload. The drugs were tolerated well without any serious adverse effects.