High-dose creatine therapy for huntington disease : A 2-year clinical and MRS study

• Published in: Neurology Vol. 64; no. 9; pp. 1655 - 1656
• Main Authors: TABRIZI, S. J, BLAMIRE, A. M, MANNERS, D. N, RAJAGOPALAN, B, STYLES, P, SCHAPIRA, A. H. V, WARNER, T. T
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 10-05-2005
• Subjects: Administration, Oral; Aspartic Acid - analogs & derivatives; Aspartic Acid - blood; Biological and medical sciences; Body Weight - drug effects; Body Weight - physiology; Brain - drug effects; Brain - metabolism; Brain - physiopathology; Creatine - administration & dosage; Creatine - adverse effects; Creatine - blood; Creatinine - blood; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dose-Response Relationship, Drug; Energy Metabolism - drug effects; Energy Metabolism - physiology; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Huntington Disease - diagnosis; Huntington Disease - drug therapy; Huntington Disease - metabolism; Magnetic Resonance Spectroscopy; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neuropsychological Tests; Patient Compliance; Phosphocreatine - blood; Pilot Projects; Treatment Outcome; Up-Regulation - drug effects; Up-Regulation - physiology; Nervous system diseases; Treatment; Central nervous system disease; Huntington disease; Degenerative disease; Creatine; High dose; Cerebral disorder; Extrapyramidal syndrome; Genetic disease
• ISSN: 0028-3878; 1526-632X
• DOI: 10.1212/01.WNL.0000160388.96242.77