Acute disseminated encephalomyelitis following nephropathia epidemica

• Published in: Acta neurologica Scandinavica Vol. 105; no. 4; pp. 333 - 336
• Main Authors: Toivanen, A.‐L., Valanne, L., Tatlisumak, T.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing 01-04-2002; Blackwell
• Subjects: acute disseminated encephalomyelitis (ADEM); Biological and medical sciences; Encephalomyelitis, Acute Disseminated - diagnosis; Encephalomyelitis, Acute Disseminated - etiology; Female; Hantavirus Infections - complications; Hantavirus Infections - diagnosis; Hemorrhagic Fever with Renal Syndrome - complications; Hemorrhagic Fever with Renal Syndrome - diagnosis; Human viral diseases; Humans; Infectious diseases; Magnetic Resonance Imaging; Medical sciences; Middle Aged; nephropathia epidemica; Puumala virus; Viral diseases; Viral diseases of the genital and urinary system; Europe; Finland; Kidney disease; Human; Hemorrhagic fever; Nervous system diseases; Urinary system disease; Encephalomyelitis; Acute; Cerebral disorder; Infection; Virus; Case study; Bunyaviridae; Puumala virus; Viral disease; Arbovirus disease; Central nervous system disease; Complication; Dialysis; Hantavirus; Disseminated; Spinal cord disease; Endemic nephropathy
• ISSN: 0001-6314; 1600-0404
• DOI: 10.1034/j.1600-0404.2002.1c168.x

Acute disseminated encephalomyelitis (ADEM) is an acute monophasic inflammatory and demyelinating disease of the central nervous system (CNS) occurring days to weeks after a virus infection or vaccination. Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome caused by Puumala virus, with endemic regions in Europe, especially Scandinavia and Western Russia. We describe a case of severe nephropathia epidemica requiring dialysis, followed by severe CNS symptoms caused by ADEM. To our best knowledge this is the first case in the literature in which NE caused ADEM.