Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard-soft NS donor ligand

Synthesis, characterization, and DNA interaction of mononuclear copper(II) and zinc(II) complexes having a hard-soft NS donor ligand

Knoevenagel condensate-based Schiff base ligands (L) containing N and S donor sites have been designed and synthesized [L = 3-cinnamalideneacetylacetonethiosemicarbazone (CAT)/3-cinnamalideneacetylacetoneethylthiosemicarbazone (CAET)/3-cinnamalideneacetylacetonephenylthiosemicarbazone (CAPT)]. They...

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Bibliographic Details
Published in:Journal of coordination chemistry Vol. 62; no. 14; pp. 2375 - 2387
Main Authors: Raman, N., Jeyamurugan, R.
Format: Journal Article
Language:English
Published: Taylor & Francis Group 20-07-2009
Subjects:
binding constant
complexes
intercalation
nuclease activity
Schiff base
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Summary:Knoevenagel condensate-based Schiff base ligands (L) containing N and S donor sites have been designed and synthesized [L = 3-cinnamalideneacetylacetonethiosemicarbazone (CAT)/3-cinnamalideneacetylacetoneethylthiosemicarbazone (CAET)/3-cinnamalideneacetylacetonephenylthiosemicarbazone (CAPT)]. They afford complexes of the type [ML] [M = Cu(II) and Zn(II)]. Both the ligands and their complexes were characterized by analytical and spectral data. Intercalative binding of these complexes with DNA has been investigated by electronic absorption spectroscopy, viscosity measurements, cyclic voltammetry, and differential pulse voltammetry. Electrophoretic study of the complexes indicates that they efficiently cleave supercoiled pUC19 DNA in the presence of hydrogen peroxide.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958970902825195