Synthesis and Anticancer Activities of Some Thiazole Derivatives

Synthesis and Anticancer Activities of Some Thiazole Derivatives

In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl)aminophenyl]thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl]amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were...

Full description

Saved in:
Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements Vol. 184; no. 9; pp. 2197 - 2207
Main Authors: Kayagil, Ismail, Demirayak, Seref
Format: Journal Article
Language:English
Published: Taylor & Francis Group 18-09-2009
Subjects:
Anticancer activity
poly-thiazole
thiazolone
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, 2-substituted 4-[3/4-(4-arylthiazole-2-yl)aminophenyl]thiazole derivatives and 2-[4-[2-substituted 4-methylthiazole-5-yl]thiazole-2-yl]amino-5-arylidenethiazoline-4-one derivatives have been synthesized. The cytotoxic and/or growth inhibitory effects of the 16 selected compounds were evaluated in vitro against approximately 66 human tumor cell lines derived from nine neoplastic diseases. Some of the compounds were found to act as anticancer agents.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500802446181