Novel Carbon-Carbon Bond Formation between N-Methyl-3-phenyl-3-hydroxypropylamine and Cresols Catalyzed by p-Toluenesulphonic Acid
The p-toluenesulphonic acid-catalyzed reaction between appropriate cresols and N-methyl-3-phenyl-3-hydroxypropylamine in refluxing toluene resulted in the formation of o-substituted phenol derivatives by an aromatic nucleophilic substitution reaction.
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| Published in: | Synthetic communications Vol. 36; no. 13; pp. 1923 - 1926 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Taylor & Francis Group
01-07-2006
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| Abstract | The p-toluenesulphonic acid-catalyzed reaction between appropriate cresols and N-methyl-3-phenyl-3-hydroxypropylamine in refluxing toluene resulted in the formation of o-substituted phenol derivatives by an aromatic nucleophilic substitution reaction. |
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| AbstractList | The p-toluenesulphonic acid-catalyzed reaction between appropriate cresols and N-methyl-3-phenyl-3-hydroxypropylamine in refluxing toluene resulted in the formation of o-substituted phenol derivatives by an aromatic nucleophilic substitution reaction. |
| Author | Govindan, Shanmugam Sureshkumar, P. Gopalakrishnan, M. Reddy Ghanta, Mahesh Thanusu, J. Kanagarajan, V. |
| Author_xml | – sequence: 1 givenname: M. surname: Gopalakrishnan fullname: Gopalakrishnan, M. email: emgeekk@yahoo.co.in organization: Department of Chemistry , Annamalai University – sequence: 2 givenname: P. surname: Sureshkumar fullname: Sureshkumar, P. organization: Department of Chemistry , Annamalai University – sequence: 3 givenname: V. surname: Kanagarajan fullname: Kanagarajan, V. organization: Department of Chemistry , Annamalai University – sequence: 4 givenname: J. surname: Thanusu fullname: Thanusu, J. organization: Department of Chemistry , Annamalai University – sequence: 5 givenname: Shanmugam surname: Govindan fullname: Govindan, Shanmugam organization: Department of Research and Development , Dr. Reddy's Laboratories Ltd – sequence: 6 givenname: Mahesh surname: Reddy Ghanta fullname: Reddy Ghanta, Mahesh organization: Department of Research and Development , Dr. Reddy's Laboratories Ltd |
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| Cites_doi | 10.1016/0304-3940(93)90737-6 10.1590/S0103-50532005000300026 10.1016/S0040-4039(00)85993-6 |
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| Copyright | Copyright Taylor & Francis Group, LLC 2006 |
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| DOI | 10.1080/00397910600602776 |
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| EISSN | 1532-2432 |
| EndPage | 1926 |
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| References | Pataki C. S. (CIT0003) 2004; 9 Gehlert D. R. (CIT0002) 1993; 157 Kumar A. (CIT0006) 1991; 32 Strebnik M. (CIT0004) 1988; 53 Ali I. S. (CIT0005) 2003; 23 Fatima A. (CIT0007) 2005; 16 Wong D. T. (CIT0001) 1982; 222 |
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| Snippet | The p-toluenesulphonic acid-catalyzed reaction between appropriate cresols and N-methyl-3-phenyl-3-hydroxypropylamine in refluxing toluene resulted in the... |
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| StartPage | 1923 |
| SubjectTerms | Anti-depressant drug aromatic nucleophilic substitution Atomoxetine carbon-carbon bond formation cresol N-methyl-3-phenyl-3-hydroxypropylamine p-toluenesulphonic acid |
| Title | Novel Carbon-Carbon Bond Formation between N-Methyl-3-phenyl-3-hydroxypropylamine and Cresols Catalyzed by p-Toluenesulphonic Acid |
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