Novel Carbon-Carbon Bond Formation between N-Methyl-3-phenyl-3-hydroxypropylamine and Cresols Catalyzed by p-Toluenesulphonic Acid

The p-toluenesulphonic acid-catalyzed reaction between appropriate cresols and N-methyl-3-phenyl-3-hydroxypropylamine in refluxing toluene resulted in the formation of o-substituted phenol derivatives by an aromatic nucleophilic substitution reaction.

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Bibliographic Details
Published in:	Synthetic communications Vol. 36; no. 13; pp. 1923 - 1926
Main Authors:	Gopalakrishnan, M., Sureshkumar, P., Kanagarajan, V., Thanusu, J., Govindan, Shanmugam, Reddy Ghanta, Mahesh
Format:	Journal Article
Language:	English
Published:	Taylor & Francis Group 01-07-2006
Subjects:	Anti-depressant drug aromatic nucleophilic substitution Atomoxetine carbon-carbon bond formation cresol N-methyl-3-phenyl-3-hydroxypropylamine p-toluenesulphonic acid
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Description
Summary:	The p-toluenesulphonic acid-catalyzed reaction between appropriate cresols and N-methyl-3-phenyl-3-hydroxypropylamine in refluxing toluene resulted in the formation of o-substituted phenol derivatives by an aromatic nucleophilic substitution reaction.
ISSN:	0039-7911 1532-2432
DOI:	10.1080/00397910600602776