AA amyloidosis in a patient with Langerhans cell histiocytosis

AA amyloidosis in a patient with Langerhans cell histiocytosis

We report the case of a 37-year-old woman who presented with progressive renal dysfunction and proteinuria, in whom renal biopsy confirmed a diagnosis of AA amyloidosis. No evidence of chronic suppurative infection, connective tissue disease or malignancy was found. A past history of Langerhans cell...

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Bibliographic Details
Published in:NDT plus Vol. 4; no. 2; pp. 104 - 106
Main Authors: Thomson, Peter C, Taylor, Alison H M, Morris, Scott T W, Kipgen, David, Mactier, Robert A
Format: Journal Article
Language:English
Published: England Oxford University Press 01-04-2011
Subjects:
Clinical Reports
amyloid
histiocytosis
Langerhans
proteinuria
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Summary:We report the case of a 37-year-old woman who presented with progressive renal dysfunction and proteinuria, in whom renal biopsy confirmed a diagnosis of AA amyloidosis. No evidence of chronic suppurative infection, connective tissue disease or malignancy was found. A past history of Langerhans cell histiocytosis (LCH) diagnosed in childhood was noted for which the patient had been successfully treated with surgical excision, corticosteroids, radiotherapy and chemotherapy. Renal disease in LCH is not widely recognized and thus we describe a patient with LCH in whom AA amyloidosis developed in the absence of any other established cause.
ISSN:1753-0784
1753-0792
DOI:10.1093/ndtplus/sfq201