Unexplained decrease in measured oxygen saturation by pulse oximetry following injection of Lymphazurin 1% (isosulfan blue) during a lymphatic mapping procedure

• Published in: Journal of surgical oncology Vol. 70; no. 2; pp. 126 - 129
• Main Authors: Coleman, Robert L., Whitten, Charles W., O'Boyle, John, Sidhu, Bobbie
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01-02-1999; Wiley-Liss
• Subjects: absorptive spectroscopy; Adult; Biological and medical sciences; cervical cancer; Ent. Stomatology; Female; hemoglobin species; Humans; Injections; Investigative techniques, diagnostic techniques (general aspects); Lymph Node Excision; Lymph Nodes - pathology; Medical sciences; Oximetry; Oxygen - blood; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Rosaniline Dyes; sentinel node; Uterine Cervical Neoplasms - blood; Uterine Cervical Neoplasms - pathology; Human; Blood gas; Cartography; Squamous cell carcinoma; Oxygen; Pulse oxymetry; Saturation; Exploration; Lymphatic; Malignant tumor; Case study; Spectrometry; Decrease; ENT disease; Adult; Complication; Female; Neck
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/(SICI)1096-9098(199902)70:2<126::AID-JSO12>3.0.CO;2-P

A rare case of alteration in measured pulse oximetry during a lymphatic mapping procedure for cervical carcinoma is reported. Over a 5‐min period following injection of perilesional Lymphazurin 1% dye (3 ml total), a profound pulse oximetry desaturation was observed. Concomitant arterial blood gas determinations confirmed patient's well‐being. Interaction of this agent's absorptive spectroscopy and wavelengths used to measure oxygen saturation by commercial pulse oximetry devices is suspected. J. Surg. Oncol. 1999;70:126–129. © 1999 Wiley‐Liss, Inc.