Synthesis and characterization of modified bioactive arabinoxylan-psyllium: Evaluation of molecular interactions, physiochemical and biomedical properties

• Published in: International journal of biological macromolecules Vol. 221; pp. 1053 - 1064
• Main Authors: Singh, Baljit, Devi, Kavita, Sharma, Diwanshi, Sharma, Prerna
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 30-11-2022
• Subjects: Arabinoxylan; Drug delivery; Grafting; Grafting; Drug delivery; Arabinoxylan
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2022.09.064

Keeping in view the future prospectus of carbohydrate polymers, present research report is an elaboration, exploration and execution of the research expectancy in area of these polymers by researchers like John F. Kennedy. Herein, molecular interactions and physiochemical properties of modified bioactive arabinoxylan-psyllium have been evaluated for drug delivery applications. Arabinoxylan-psyllium was modified with sulphated and amide copolymers and co-polymers were characterized by SEMs, AFM, FTIR, XRD, solid state 13C NMR, TGA-DSC and water absorption studies. The 13C-NMR and FTIR confirmed grafted copolymers. The polymer-blood interactions revealed non-thrombogenic nature with thrombose percentage 63.17 ± 5.61 % and polymer-mucous membrane interactions showed detachment force 0.237 ± 0.078Nwith bio-membrane in mucoadhesion test. The pH responsible gels exhibited 44.49 ± 3.12 % inhibitions of free radicals in DPPH assay. The polymer-drug interactions demonstrated sustained diffusion of methotrexate with non-Fickian diffusion and Korsmeyer-Peppas kinetic model. Overall, co-polymeric network structure was found useful in colon specific drug delivery.