Genetic variation of the APOE promoter and outcome after head injury

• Published in: Neurology Vol. 61; no. 5; pp. 683 - 685
• Main Authors: LENDON, C. L, HARRIS, J. M, PRITCHARD, A. L, NICOLL, J. A. R, TEASDALE, G. M, MURRAY, G
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 09-09-2003
• Subjects: Adolescent; Adult; Aged; Apolipoprotein E4; Apolipoproteins E - genetics; Biological and medical sciences; Brain Injuries - diagnosis; Brain Injuries - genetics; Child; Child, Preschool; Female; Gene Frequency; Genotype; Haplotypes; Humans; Infant; Injuries of the nervous system and the skull. Diseases due to physical agents; Male; Medical sciences; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Promoter Regions, Genetic; Traumas. Diseases due to physical agents; Human; Nervous system diseases; Prognosis; Craniocerebral; Diseases of the osteoarticular system; Genotype; Trauma; Cerebral disorder; Promoter; Allele; Apolipoprotein E; Central nervous system disease; Risk factor; Skull disease; Predictive factor; Polymorphism
• ISSN: 0028-3878; 1526-632X
• DOI: 10.1212/01.WNL.0000078033.81925.80

The APOE-epsilon4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors' data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.