Prediction of Recurrence after radical surgery for gastric cancer: A scoring system obtained from a prospective multicenter study

• Published in: Annals of surgery Vol. 241; no. 2; pp. 247 - 255
• Main Authors: MARRELLI, Daniele, DE STEFANO, Alfonso, DE MANZONI, Giovanni, MORGAGNI, Paolo, DI LEO, Alberto, ROVIELLO, Franco
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01-02-2005
• Subjects: Adult; Aged; Biological and medical sciences; Female; Gastrectomy; General aspects; Humans; Lymph Node Excision; Male; Medical sciences; Middle Aged; Models, Statistical; Neoplasm Invasiveness; Neoplasm Recurrence, Local - epidemiology; Neoplasm Recurrence, Local - pathology; Original; Predictive Value of Tests; Prognosis; Prospective Studies; Reproducibility of Results; Risk Assessment; Risk Factors; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Medicine; Prospective; Recurrence; Relapse; Treatment; Evaluation scale; Surgery; Multicenter study; Prediction; Predictive factor; Stomach cancer; Radical
• ISSN: 0003-4932; 1528-1140
• DOI: 10.1097/01.sla.0000152019.14741.97

The aim of this prospective multicenter study was to define a scoring system for the prediction of tumor recurrence after potentially curative surgery for gastric cancer.
The estimation of the risk of recurrence in individual patient may be relevant in clinical practice, to apply adjuvant therapies after surgery, and plan an adequate follow-up program. Only a few studies, most of which were retrospective or performed on a limited number of patients, have developed a prognostic score in patients with gastric cancer.
A total of 536 patients who underwent UICC R0 resection between 1988 and 1998 at 3 surgical departments in Italy were considered. All patients were followed up using a standard protocol after discharge from the hospital. The mean follow-up period was 56 +/- 44 months, and 94 +/- 29 months for surviving patients. The scoring system was calculated on the basis of a logistic regression model, where the presence of the recurrence was the dependent variable, and clinicopathologic variables were the covariates.
Recurrence occurred in 272 of 536 patients (50.7%). The scoring system for the prediction of the risk in individual cases gave values ranging from 1.4 to 99.9; the model distributed most cases in the extremes of the range. The risk of recurrence increased remarkably with score values; it was only 5% in patients with a score below 10, up to 95.4% in patients with a score of 91 to 100. No recurrence was observed in 43 patients with a score below 4, whereas all of the 56 patients with a score over 97 presented a recurrence. The model correctly predicted recurrence in 227 of 272 patients (sensitivity, 83.5%), whereas the absence of recurrence was correctly predicted in 214 of 264 patients (specificity, 81.1%); the overall accuracy was 82.2%. Prognostic score was clearly superior to UICC tumor stage in predicting recurrence. The high effectiveness of the score was confirmed in preliminary data of a validation study.
The scoring system obtained with a regression model on the basis of our follow-up data is useful for defining subgroups of patients at a very low or very high risk of tumor recurrence after radical surgery for gastric cancer. Final results of the validation study are essential for a clinical application of the model.