Effect of preoperative chemotherapy on the outcome of surgical treatment of vertebral tuberculosis : retrospective analysis of 434 cases

• Published in: Archives of orthopaedic and trauma surgery Vol. 121; no. 1-2; pp. 65 - 66
• Main Authors: ALICI, Emin, AKCALI, Ömer, TATARI, Hasan, GÜNAL, Izge
• Format: Journal Article
• Language: English
• Published: Berlin Springer 2001; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antitubercular Agents - therapeutic use; Biological and medical sciences; Chemotherapy; Child; Combined Modality Therapy; Debridement - methods; Drug Therapy, Combination; Ethambutol - therapeutic use; Female; Humans; Isoniazid - therapeutic use; Male; Medical sciences; Middle Aged; Patient Selection; Pharmacology. Drug treatments; Premedication - methods; Preoperative Care - methods; Recurrence; Retrospective Studies; Rifampin - therapeutic use; Time Factors; Treatment Outcome; Tuberculosis; Tuberculosis, Spinal - diagnosis; Tuberculosis, Spinal - drug therapy; Tuberculosis, Spinal - surgery; Human; Prognosis; Treatment efficiency; Diseases of the osteoarticular system; Vertebra; Duration; Mycobacterial infection; Spine disease; Infection; Chemotherapy; Orthopedic surgery; Tuberculosis; Mycobacterium tuberculosis; Mycobacteriales; Correlation analysis; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes; Antituberculous agent; Combined treatment; Preoperative
• ISSN: 0936-8051; 1434-3916
• DOI: 10.1007/s004020000163

A retrospective analysis of 434 patients with vertebral tuberculosis who were treated surgically was performed with special reference to the preoperative duration of chemotherapy. Of these, 376 underwent 4 weeks of a chemotherapy regimen with isoniazid, rifampin and ethamburol, and in 2 re-activation of the disease was observed. The remaining 58 underwent operation for neurological impairment with 6-18 h of the same chemotherapy regimen, and in no case did re-activation occur. These results suggest a shorter duration of chemotherapy may be utilised in all patients undergoing surgical treatment for vertebral tuberculosis, providing a thorough debridement is performed, leaving no necrotic or infected tissue behind.