Glycolipids from macroalgae: potential biomolecules for marine biotechnology?

Glycolipids from macroalgae: potential biomolecules for marine biotechnology?

Brown, red and green algae from the Southeastern coast of Brazil were successively extracted with chloroform/methanol 2:1 and 1:2 (v/v). The crude lipid extract was partitioned according to Folch and the lower phase enriched in glycolipids was fractionated on a silica gel column chromatography elute...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia Vol. 21; no. 2; pp. 244 - 247
Main Authors: Mattos, Bianca B., Romanos, Maria Teresa V., Souza, Lauro M. de, Sassaki, Guilherme, Barreto-Bergter, Eliana
Format: Journal Article
Language:English
Published: Sociedade Brasileira de Farmacognosia 01-04-2011
Subjects:
PHARMACOLOGY & PHARMACY
marine macroalgae
glycolipids
antiviral activity
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Summary:Brown, red and green algae from the Southeastern coast of Brazil were successively extracted with chloroform/methanol 2:1 and 1:2 (v/v). The crude lipid extract was partitioned according to Folch and the lower phase enriched in glycolipids was fractionated on a silica gel column chromatography eluted with chloroform, acetone and methanol. Three major orcinol-reactive bands present in the acetone and methanol fractions were detected by thin-layer chromatography with chromatographic mobilities corresponding to sulfoglycolipids and glycosyldiacylglycerols. These fractions exhibited potent antiviral activity against HSV-1-ACVs and HSV-1-ACVr and present low toxicity for cell cultures. Purification and identification of these bioactive glycolipids will be necessary in order to elucidate their primary structures and mechanism of action.
ISSN:0102-695X
1981-528X
DOI:10.1590/S0102-695X2011005000056