The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism

• Published in: Journal of endocrinological investigation Vol. 39; no. 6; pp. 709 - 713
• Main Authors: Shatynska-Mytsyk, I., Rodrigo, L., Cioccocioppo, R., Petrovic, D., Lakusic, N., Compostella, L., Novak, M., Kruzliak, P.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-06-2016
• Subjects: Adult; Case-Control Studies; Echocardiography, Doppler; Endocrinology; Female; Hormone Replacement Therapy - adverse effects; Humans; Hypothyroidism - complications; Hypothyroidism - drug therapy; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Prospective Studies; Rapid Communication; Thyroxine - adverse effects; Ventricular Dysfunction, Left - chemically induced; Ventricular Function, Left - drug effects; Heart failure; Left ventricular diastolic function; Echocardiography; Subclinical hypothyroidism
• ISSN: 1720-8386; 1720-8386
• DOI: 10.1007/s40618-015-0262-2

Objective
Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of
l
-thyroxine (6.25–25 µg/day) on left ventricular diastolic function in patients with SH.
Materials and methods
33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT.
Results
At baseline, patients with SH showed significantly lower
E
(0.79 ± 0.22 vs. 0.93 ± 0.19,
p
 < 0.001),
E
/
A
ratio (1.19 ± 0.29 vs. 1.31 ± 0.25,
p
 < 0.003), and higher intraventricular septum thickness (IVST) (0.99 ± 0.14 vs. 0.89 ± 0.18,
p
 < 0.001) in comparison with healthy controls. After 6 months of therapy, the
E
/
A
ratio underwent significant increase (1.28 ± 0.21 vs. 1.19 ± 0.29,
p
 < 0.001), while the IVS displayed a robust reduction (0.92 ± 0.16 vs. 0.99 ± 0.14,
p
 < 0.001).
Conclusions
HRT with low-dosed
l
-thyroxine may improve left ventricular diastolic function in patients with SH.