Synthesis, antiherpes, and antibacterial activity of N-linked conjugates of eremomycin with adamantanecarboxylic acids

N¹-linked conjugates of eremomycin with 1-adamantylacetic and p-(1-adamantyl)phenoxyacetic acids were synthesized for the first time. Their activity against herpes simplex virus 2 (HSV-2) was demonstrated (SI ∼ 10). At the same time, modification of the N-methylleucine fragment of eremomycin with ad...

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Bibliographic Details
Published in:	Pharmaceutical chemistry journal Vol. 43; no. 9; pp. 485 - 490
Main Authors:	Kovalev, V. V, Alimbarova, L. M, Shokova, E. A, Katrukha, G. S
Format:	Journal Article
Language:	English
Published:	Boston Boston : Springer US 01-09-2009 Springer US
Subjects:	Activity adamantylated eremomycin antibacterial and antiviral Herpes simplex virus 2 Medicine Organic Chemistry Pharmacology/Toxicology Pharmacy Search for New Drugs semisynthetic glycopeptide antibiotics antibacterial and antiviral adamantylated eremomycin Activity semisynthetic glycopeptide antibiotics
Online Access:	Get full text
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Summary:	N¹-linked conjugates of eremomycin with 1-adamantylacetic and p-(1-adamantyl)phenoxyacetic acids were synthesized for the first time. Their activity against herpes simplex virus 2 (HSV-2) was demonstrated (SI ∼ 10). At the same time, modification of the N-methylleucine fragment of eremomycin with adamantanecarboxylic acids led to some decrease in antibacterial activity.
Bibliography:	http://dx.doi.org/10.1007/s11094-009-0342-8 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-009-0342-8