One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphology and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functi...

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Bibliographic Details
Published in:	Nano research Vol. 13; no. 6; pp. 1592 - 1596
Main Authors:	Cui, Mingyue, Wiraja, Christian, Qi, Lim Wei, Ting, Sharon Chew Wan, Jana, Deblin, Zheng, Mengjia, Hu, Xiao, Xu, Chenjie
Format:	Journal Article
Language:	English
Published:	Beijing Tsinghua University Press 01-06-2020 Springer Nature B.V
Subjects:	Antibodies Atomic/Molecular Structure and Spectra Biocompatibility Biomedicine Biotechnology Chemistry and Materials Science Condensed Matter Physics Drug carriers Drug delivery Folic acid Labeling Materials Science Morphology Nanoparticles Nanotechnology Research Article Silica Silicon dioxide one-step synthesis silica nanoparticles surface modification bacterial & cell labelling
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Summary:	Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility, controllable morphology and so on. They can be used both as the drug carrier and imaging vehicle. Here, an aminated ultra-small silica nanoparticle based system is developed with various functionalities. Multiple molecules including fluorophore, folic acid, and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.
ISSN:	1998-0124 1998-0000
DOI:	10.1007/s12274-020-2775-z