Influence of the MIF polymorphism −173G > C on Turkish postmenopausal women with osteoporosis

• Published in: Zeitschrift für Rheumatologie Vol. 77; no. 7; pp. 629 - 632
• Main Authors: Ozsoy, A. Z., Karakus, N., Tural, S., Yigit, S., Kara, N., Alayli, G., Tumer, M. K., Kuru, O.
• Format: Journal Article
• Language: English
• Published: Munich Springer Medizin 01-09-2018
• Subjects: Aged; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Immunology; Internal Medicine; Intramolecular Oxidoreductases - genetics; Laboratory Medicine; Macrophage Migration-Inhibitory Factors - genetics; Medicine; Medicine & Public Health; Middle Aged; Originalie; Orthopedics; Osteoporosis, Postmenopausal - genetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Postmenopause; Rheumatology; Turkey; Turkey; Osteoporosis; Genetic susceptibility; Genetische Prädisposition; Osteoporose; Polymorphismus; MIF; Polymorphism
• ISSN: 0340-1855; 1435-1250
• DOI: 10.1007/s00393-017-0382-5

Background
MIF, a proinflammatory cytokine, contributes to the pathogenesis of acute, chronic, and autoimmune inflammatory disorders and balances the suppressive effect of glucocorticoids on the immune system. There is an interaction between bone metabolism and the immune system via the production of cytokines. We aimed to analyze the relationship between the
MIF
gene −173G > C promoter polymorphism and osteoporosis.
Methods
In this case–control study performed in a university hospital, 286 samples (136 women with osteoporosis and 150 healthy age-matched controls) participated. The polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) assay was used to genotype the
MIF
gene polymorphism. The alleles and genotypes frequencies of patients and controls were compared using the χ
2
test.
Results
The genotype frequencies of
MIF
gene −173G > C polymorphism showed statistically significant differences between patients and controls (
p
 = 0.038). Also, the subjects carrying the variant C allele in the MIF −173 position were at significantly higher risk of osteoporosis than subjects carrying the wild-type G allele (
p
 = 0.009, odds ratio 1.7, 95% confidence interval 1.1–2.6).
Conclusion
Our study suggested a strong association between
MIF
gene −173G > C polymorphism and osteoporosis in a Turkish population.