The Effect of a Lipopolysaccharide from Rhodobacter capsulatus PG on Inflammation Caused by Various Influenza Strains

• Published in: Actanaturae Vol. 11; no. 3; pp. 46 - 55
• Main Authors: Zubova, S. V., Vorovich, M. F., Gambaryan, A. S., Ishmukhametov, A. A., Grachev, S. V., Prokhorenko, I. R.
• Format: Journal Article
• Language: English
• Published: A.I. Gordeyev 01-07-2019
• ISSN: 2075-8251
• DOI: 10.32607/20758251-2019-11-3-46-55

The development of a specific inflammation in mice that had been infected by two influenza virus strains, A/chicken/Kurgan/5/2005 (H5N1) and A/Hamburg/2009 MA (H1N1), was studied. We investigated the effect of a non-toxic lipopolysaccharide from Rhodobacter capsulatus PG on the survival and body weight of the mice, production of IgG antibodies, and the induction of pro- and anti-inflammatory cytokines in blood serum. The administration of the R. capsulatus PG lipopolysaccharide was shown to induce interferon- synthesis, both in healthy and influenza A virus-infected mice, and to promote production of antiviral antibodies in the blood of the influenza-infected animals.