Chronic Chagastic cardiomyopathy associated with membranoproliferative glomerulonephritis: Report of an autopsy case

• Published in: Pathology international Vol. 70; no. 1; pp. 47 - 52
• Main Authors: Shintaku, Masayuki, Takeda, Shinsaku, Miura, Sachio, Yutani, Chikao, Tsutsumi, Yutaka
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01-01-2020
• Subjects: Autopsies; Autopsy; Cardiomyopathy; Chagas disease; chronic Chagastic cardiomyopathy; Chronic infection; Fibrosis; Glomerulonephritis; Heart diseases; Infections; membranoproliferative glomerulonephritis; Myocarditis; Pathogenesis; Persistent infection; Protozoa; Signs and symptoms; trypanosoma cruzi; Vector-borne diseases; chronic Chagastic cardiomyopathy; membranoproliferative glomerulonephritis; trypanosoma cruzi
• ISSN: 1320-5463; 1440-1827
• DOI: 10.1111/pin.12883

An autopsy case of chronic Chagas disease, a debilitating disorder caused by persistent infection by protozoa, Trypanosoma cruzi (Tr. cruzi), is reported. The patient was a 73‐year‐old Brazilian woman of Japanese descent, who had emigrated to Japan at the age of about 40 years. She died of chronic cardiac insufficiency about 8 years after the onset of cardiac symptoms. At autopsy, the heart showed typical features of chronic Chagastic cardiomyopathy: chronic lymphocytic myocarditis with extensive fibrosis and the formation of an apical aneurysm. The pathogenic protozoa were not detected in the cardiac tissue. The kidney showed typical features of membranoproliferative glomerulonephritis (MPGN). On the basis of experimental data which suggested that chronic infection of Tr. cruzi could elicit immune complex‐mediated glomerulonephritis, we considered that the chronic persistent infection by Tr. cruzi contributed to the pathogenesis of MPGN in this patient.