The Metabolic Syndrome in Polycystic Ovary Syndrome

Approximately one-third to one-half of all women and adolescent girls with polycystic ovary syndrome (PCOS) has the metabolic syndrome, associated with increased risk for cardiovascular disease and type 2 diabetes. Evidence suggests that insulin resistance is the likely link between PCOS and the met...

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Bibliographic Details
Published in:	Clinical obstetrics and gynecology Vol. 50; no. 1; pp. 205 - 225
Main Authors:	ESSAH, PAULINA A, WICKHAM, EDMOND P, NESTLER, JOHN E
Format:	Journal Article
Language:	English
Published:	United States Lippincott Williams & Wilkins, Inc 01-03-2007
Subjects:	Adolescent Adult Cardiovascular Diseases - complications Diabetes Mellitus, Type 2 Evidence-Based Medicine Female Humans Metabolic Syndrome - complications Metabolic Syndrome - therapy Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - diagnosis Prevalence Risk Factors
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Summary:	Approximately one-third to one-half of all women and adolescent girls with polycystic ovary syndrome (PCOS) has the metabolic syndrome, associated with increased risk for cardiovascular disease and type 2 diabetes. Evidence suggests that insulin resistance is the likely link between PCOS and the metabolic syndrome. Early screening for impaired glucose tolerance, even in adolescents, is recommended. Lifestyle modification with increased physical activity and weight reduction remains first-line therapy. Insulin-sensitizing drugs may also ameliorate features of the metabolic syndrome in PCOS but long-term prospective studies are needed to determine the role of these drugs in the prevention of the metabolic syndrome.
ISSN:	0009-9201 1532-5520
DOI:	10.1097/GRF.0b013e31802f3547