Hepatic injuries resulting from chronic alcohol abuse identified by forensics

Alcohol intake is largely spread all over the world, although it is well-known that it causes important changes of the liver, from liver steatosis, hepatitis to liver cirrhosis. The study we performed on 93 patients deceased in suspicious circumstances and brought to the Institute of Forensic Medici...

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Bibliographic Details
Published in:	Romanian journal of morphology and embryology Vol. 62; no. 3; pp. 819 - 827
Main Authors:	Crauciuc, Dragoş Valentin, Stan, Cristinel Ionel, Rîşcanu, Laura Adriana, Predescu, Octavian Ion, Bulgaru-Iliescu, Diana
Format:	Journal Article
Language:	English
Published:	Romania Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 01-07-2021
Subjects:	Alcoholism - complications Forensic Medicine Humans Kupffer Cells Liver Liver Diseases, Alcoholic Original Paper
Online Access:	Get full text
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Summary:	Alcohol intake is largely spread all over the world, although it is well-known that it causes important changes of the liver, from liver steatosis, hepatitis to liver cirrhosis. The study we performed on 93 patients deceased in suspicious circumstances and brought to the Institute of Forensic Medicine, Iaşi, Romania, confirmed through the determination of Ethyl glucuronide, that these were alcohol consumers. The macroscopic analysis during necropsy highlighted the presence of alcoholic liver disease (ALD), while microscopy studies confirmed the macroscopic observations. The immunohistochemical studies showed the existence of a chronic liver inflammation, the transdifferentiation of stellate hepatic cells, the activation of Kupffer cells, important changes of the hepatic vascular network, hepatocyte necrosis, lipid loadings and the progression of liver fibrosis process.
ISSN:	1220-0522 2066-8279
DOI:	10.47162/RJME.62.3.20