UFU (‘Ullmann–Finkelstein–Ullmann’): a new multicomponent reaction

UFU (‘Ullmann–Finkelstein–Ullmann’): a new multicomponent reaction

The development of a Ullmann–Finkelstein–Ullmann multicomponent reaction and its application to the synthesis of nonsymmetrical para-disubstituted benzene compounds are described. We developed conditions to carry out the first ‘one-pot’ Ullmann–Finkelstein–Ullmann multicomponent reaction reported. T...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 47; no. 28; pp. 4973 - 4978
Main Authors: Toto, Patrick, Gesquière, Jean-Claude, Cousaert, Nicolas, Deprez, Benoit, Willand, Nicolas
Format: Journal Article
Language:English
Published: Elsevier Ltd 12-07-2006
Elsevier
Subjects:
Life Sciences
Pharmaceutical sciences
réactions tandem
réactions cupro-catalysées
Online Access:Get full text
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Summary:The development of a Ullmann–Finkelstein–Ullmann multicomponent reaction and its application to the synthesis of nonsymmetrical para-disubstituted benzene compounds are described. We developed conditions to carry out the first ‘one-pot’ Ullmann–Finkelstein–Ullmann multicomponent reaction reported. This reaction allows the one-pot synthesis of dissymmetrical para-disubstituted benzene scaffold from 1-bromo-4-iodobenzene and two N-nucleophiles. CuI/ N, N′-dimethyl-cyclohexane-1,2-diamine was used as a catalyst/ligand couple, K 3PO 4 as a base and the reaction was performed in dioxane.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.04.041