Microbiological bio-reduction of prochiral carbonyl compounds by antimycotic agent Boni Protect

• Published in: Catalysis communications Vol. 101; pp. 81 - 84
• Main Authors: Kołodziejska, Renata, Studzińska, Renata, Kwit, Marcin, Jelecki, Maciej, Tafelska-Kaczmarek, Agnieszka
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-11-2017
• Subjects: Antifungal agent; Aureobasidium pullulans; Biocatalysis; Microbiological reduction; Saccharomyces cerevisiae; Stereochemistry; Antifungal agent; Biocatalysis; Stereochemistry; Microbiological reduction; Aureobasidium pullulans; Saccharomyces cerevisiae
• ISSN: 1566-7367; 1873-3905
• DOI: 10.1016/j.catcom.2017.07.021

The selective properties of the fungus Aureobasidium pullulans, in the antifungal agent Boni Protect, were investigated in the fermentative bioreduction of selected carbonyl compounds. Catalyzed by oxidoreductases contained in the microorganism Aureobasidium pullulans highly enantioselective biotransformation of prochiral ketones provides the secondary alcohols when the reaction is done in the presence of specific additives. Aureobasidium pullulans has also proved to be an effective bioreagent in the reduction of α- and β-keto esters. Optically pure hydroxy esters were obtained under fermentation conditions without the use of additives.
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•Antimycotic agent Boni Protect was used for the enantioselective bio-reduction.•The microbiological reduction of ketones, and keto esters were investigated.•Chiral alcohols and hydroxy esters were obtained in high optical purity.