Kynurenic acid prevented social recognition deficits induced by MK-801 in rats

MK-801 impaired social recognition potency of adult male rats when given immediately after the initial interaction with a juvenile rat. Administration of kynurenic acid prior to the initial interaction protected the adults against recognition deficits induced by MK-801. When re-exposed at a delay of...

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Bibliographic Details
Published in:	Physiological research Vol. 52; no. 6; pp. 805 - 808
Main Authors:	Hlinák, Z, Krejcí, I
Format:	Journal Article
Language:	English
Published:	Czech Republic 2003
Subjects:	Animals Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Kynurenic Acid - administration & dosage Kynurenic Acid - pharmacology Male Memory Disorders - chemically induced Memory Disorders - prevention & control Olfactory Pathways - physiology Rats Rats, Wistar Recognition (Psychology) - drug effects Social Behavior
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Summary:	MK-801 impaired social recognition potency of adult male rats when given immediately after the initial interaction with a juvenile rat. Administration of kynurenic acid prior to the initial interaction protected the adults against recognition deficits induced by MK-801. When re-exposed at a delay of 30 min to the familiar juvenile, social investigation in the adults was significantly reduced. Thus, the adults are able to remember olfactory stimuli emitted by juvenile con-specifics.
ISSN:	0862-8408 1802-9973
DOI:	10.33549/physiolres.930427