Detection of transcriptionally active hepatitis B virus DNA in peripheral mononuclear blood cells after infection during immunosuppressive chemotherapy using the polymerase chain reaction

Using PCR we have studied mononuclear peripheral blood leucocytes (PMBLs) from HBV-infected immunosuppressed patients in order to detect the presence of HBV genomes. Our results indicate that non-transient PMBL infection is common in immunotolerant carriers. In addition, the presence of pregenomic m...

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Bibliographic Details
Published in:	Archives of virology. Supplementum Vol. 4; p. 50
Main Authors:	Repp, R, Mance, A, Keller, C, Rhiel, S, Gerlich, W H, Lampert, F
Format:	Journal Article
Language:	English
Published:	Austria 1992
Subjects:	Adolescent Child Child, Preschool DNA, Viral - blood Genome, Viral Hepatitis B - etiology Hepatitis B - genetics Humans Immunosuppression Leukocytes, Mononuclear - microbiology Neoplasms - drug therapy Polymerase Chain Reaction Transcription, Genetic
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Summary:	Using PCR we have studied mononuclear peripheral blood leucocytes (PMBLs) from HBV-infected immunosuppressed patients in order to detect the presence of HBV genomes. Our results indicate that non-transient PMBL infection is common in immunotolerant carriers. In addition, the presence of pregenomic mRNA sequences suggests that virus replication may take place in PMBLs, possibly implicating the latter as a source of virus after replication has ceased in the liver.
ISSN:	0939-1983
DOI:	10.1007/978-3-7091-5633-9_11