Electrocatalytic glucose sensor

• Published in: Medical & biological engineering & computing Vol. 32; no. 3; pp. 247 - 252
• Main Authors: LAGER, W, LUCADOU, I. V, PREIDEL, W, RUPRECHT, L, SAAGER, S
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01-05-1994
• Subjects: Animals; Aspirin - pharmacology; Biological and medical sciences; Biosensing Techniques; Blood Glucose - analysis; Blood Glucose - drug effects; Cysteine - pharmacology; Electrochemistry; Electrodes, Implanted; Endocrinology; Ethanol - pharmacology; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Sheep; Endocrinopathy; Performance evaluation; Biochemical analysis; Implant; Measurement sensor; Interference; Instrumentation; Glucose; Experimental study; Long term; Electrocatalysis; In vivo; Vertebrata; Mammalia; Animal; Sheep; Artiodactyla; Technique; Ungulata; Biomedical engineering
• ISSN: 0140-0118; 1741-0444
• DOI: 10.1007/BF02512518

An electrocatalytic glucose sensor for in vivo application has been developed. The sensor is a flow-through cell with three electrodes and can be integrated into a blood vessel. The principle of measurement is based on the direct electrochemical oxidation of glucose at a membrane-covered noble-metal electrode. To test the potential long-term in vivo function of the sensor, it was implanted in the carotid artery of a sheep. Thus, the sensor performance was verified over a period of 71 days. During this time, a nearly constant blood flow through the cell was achieved, which indicates good blood compatibility of the materials used. It was possible to set up a calibration that was valid over 24 days (mean error 2.3 mmol l-1). The tested cross-sensitivity of the sensor towards cysteine, acetyl salicylic acid and other small molecules shows tolerable effects on this type of glucose measurement. Only high concentrations of lactate and ethanol require a special adaptation of the calibration to suppress their influence. Minor cross-sensitivity and promising long-term stability recommend this type of sensor for in vivo monitoring of blood sugar level. However, for intravasal application, it is necessary to modify the present sensor design to a catheter-type construction.