Influence of chemical nature of carrier materials on the dissolution behavior of racemic ibuprofen

• Published in: The Journal of supercritical fluids Vol. 132; pp. 91 - 98
• Main Authors: Reiser, Sarah, Sun, Miaotian, Johannsen, Monika, Türk, Michael
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-02-2018
• Subjects: Bioavailability; Dissolution behavior; Racemic ibuprofen; scCO2; Silica carrier; β-Cyclodextrin; Dissolution behavior; Racemic ibuprofen; β-Cyclodextrin; Silica carrier; Bioavailability; scCO2
• ISSN: 0896-8446; 1872-8162
• DOI: 10.1016/j.supflu.2017.02.015

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•The controlled particle deposition process was successfully applied to load ibuprofen onto different carrier materials.•The experimental results of this study show that drug loadings up to 50 wt% drug onto silica could be achieved.•The drug loading accumulates with increasing surface area of the silica materials.•The study has revealed that the dissolution rate of all materials investigated increases with increasing pH-value.
The poor aqueous solubility of ibuprofen due to its hydrophobicity limits the bioavailability of the drug in the aqueous environment of the human body. Therefore particle deposition experiments were performed with ibuprofen and different carrier materials. Furthermore, the dissolution behavior of the untreated ibuprofen and the ibuprofen loaded carriers has been investigated at 310K and pH=2.0 and pH=5.5.
The results of this investigation demonstrate that drug loadings up to 50 wt% drug onto silica materials could be achieved and that the drug loading increases nearly linear with increasing surface area of the silica materials. Furthermore, the study reveals that the highest dissolution rate was obtained with β-cyclodextrin and that the dissolution rate of all materials investigated increases with increasing pHvalue.