Peripheral Arterial Disease Associated With Caries and Periodontal Disease

• Published in: Journal of periodontology (1970) Vol. 84; no. 4; pp. 486 - 494
• Main Authors: Soto‐Barreras, Uriel, Olvera‐Rubio, Javier O., Loyola‐Rodriguez, Juan P., Reyes‐Macias, Juan F., Martinez‐Martinez, Rita E., Patiño‐Marin, Nuria, Martinez‐Castañon, Gabriel A., Aradillas‐Garcia, Celia, Little, James W.
• Format: Journal Article
• Language: English
• Published: United States American Academy of Periodontology 01-04-2013
• Subjects: Adult; Ankle Brachial Index; Atherosclerosis; C-Reactive Protein - analysis; Case-Control Studies; Chi-Square Distribution; C‐reactive protein; dental caries; Dental Caries - complications; Dental Plaque - microbiology; Dentistry; DMF Index; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Periodontal Attachment Loss - complications; Periodontal Index; periodontitis; Periodontitis - complications; Periodontitis - microbiology; peripheral arterial disease; Peripheral Arterial Disease - complications; tooth loss; Tooth Loss - complications
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2012.120051

Background: Peripheral arterial disease (PAD) is an important cardiovascular disorder of the peripheral arteries. Chronic infections, such as periodontitis, may play an important role in the etiology and pathophysiology of PAD and other cardiovascular conditions. Recently, Streptococcus mutans has been found with high frequency in atheromatous plaques. The aim of this study is to evaluate the possible clinical and microbiologic association between PAD and periodontitis and dental caries.
Methods: Thirty patients with PAD and 30 control individuals were selected. PAD and its severity were established by the use of the ankle‐branchial index (ABI). Clinical attachment loss (AL); probing depth; decayed, missing, and filled teeth (DMFT) index; and C‐reactive protein (CRP) levels were evaluated. The presence of bacterial DNA from Streptococcus mutans, Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia, Treponema denticola, and Aggregatibacter actinomycetemcomitans was identified by polymerase chain reaction in subgingival biofilm and serum.
Results: Patients with ≥30% AL ≥ 4 mm had six‐fold increased risk of having PAD (odds ratio = 8.18; 95% confidence interval = 1.21 to 35.23; P = 0.031). There was statistical difference in the CRP (P = 0.0413) and DMFT index (P = 0.0002), with elevated number of missing teeth (P = 0.0459) in the PAD group compared with the control group. There were no significant differences in the frequency of bacteria in serum and subgingival plaque.
Conclusion: There was a positive relationship between periodontitis based on AL and PAD determined by the ABI (odds ratio = 8.18).