Susceptibility of clinical isolates of Staphylococcus aureus to killing by oxacillin

Sixty clinical isolates of Staphylococcus aureus have been screened for their relative susceptibility to the killing action of oxacillin. Only one of these strains was found to be exceptionally resistant to the bactericidal effect of this and other beta-lactam antibiotics. This ability to survive ox...

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Bibliographic Details
Published in:	Canadian journal of microbiology Vol. 21; no. 11; p. 1692
Main Authors:	Best, G K, Koval, A V, Best, N H
Format:	Journal Article
Language:	English
Published:	Canada 01-11-1975
Subjects:	Anti-Bacterial Agents - pharmacology Humans Lactams - pharmacology Methylnitronitrosoguanidine - pharmacology Mutagens Oxacillin - pharmacology Penicillin Resistance Species Specificity Staphylococcal Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development
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Summary:	Sixty clinical isolates of Staphylococcus aureus have been screened for their relative susceptibility to the killing action of oxacillin. Only one of these strains was found to be exceptionally resistant to the bactericidal effect of this and other beta-lactam antibiotics. This ability to survive oxacillin inhibition of cell wall synthesis has been called "tolerance". The characteristics of the tolerant organism, which has been designated the Evans strain, in comparison with other isolates of S. aureus indicate that this form of resistance is not apparent from the minimal inhibitory concentration, is not related to an abnormal growth rate, and can be enhanced by treatment with N-methyl-N'-nitro-N-nitrosoguanidine.
ISSN:	0008-4166
DOI:	10.1139/m75-248