Flavonoids effects against bacteria associated to periodontal disease and dental caries: a scoping review

• Published in: Biofouling (Chur, Switzerland) Vol. 40; no. 2; pp. 99 - 113
• Main Authors: Carneiro, Bruna Tavares, de Castro, Fernanda Novais Arantes Maciel, Benetti, Francine, Nima, Gabriel, Suzuki, Thais Yumi Umeda, André, Carolina Bosso
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 07-02-2024; Taylor & Francis Ltd
• Subjects: anti-bacterial agents; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antibiotics; Antiinfectives and antibacterials; Bacteria; Bacteriostats; Biofilms; Criteria; Dental caries; Dental Caries - prevention & control; Flavonoids; Flavonoids - pharmacology; Humans; Periodontal disease; Periodontal diseases; Periodontal Diseases - drug therapy; Periodontal Diseases - microbiology; periodontitis; Porphyromonas gingivalis; Quercetin; Streptococcus mutans; dental caries; Flavonoids; anti-bacterial agents; periodontitis
• ISSN: 0892-7014; 1029-2454
• DOI: 10.1080/08927014.2024.2321965

This scoping review focused on exploring the efficacy of flavonoids against bacteria associated with dental caries and periodontal diseases. Inclusion criteria comprise studies investigating the antibacterial effects of flavonoids against bacteria linked to caries or periodontal diseases, both pure or diluted in vehicle forms. The search, conducted in August 2023, in databases including PubMed/MEDLINE, Scopus, Web of Science, Embase, LILACS, and Gray Literature. Out of the initial 1125 studies, 79 met the inclusion criteria, majority in vitro studies. Prominent flavonoids tested included epigallocatechin-gallate, apigenin, quercetin, and myricetin. Predominant findings consistently pointed to bacteriostatic, bactericidal, and antibiofilm activities. The study primarily investigated bacteria associated with dental caries, followed by periodontopathogens. A higher number of publications presented positive antibacterial results against Streptococcus mutans in comparison to Porphyromonas gingivalis. These encouraging findings underline the potential applicability of commercially available flavonoids in materials or therapies, underscoring the need for further exploration in this field.