Regulation by thyroid hormone of microtubule assembly and neuronal differentiation

• Published in: Neurochemical research Vol. 16; no. 9; pp. 975 - 982
• Main Authors: NUNEZ, J, COUCHIE, D, ANIELLO, F, BRIDOUX, A. M
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 01-09-1991
• Subjects: Animals; Biochemistry and metabolism; Biological and medical sciences; Cell Differentiation - physiology; Cell Movement - physiology; Central nervous system; Cerebellum - growth & development; Fundamental and applied biological sciences. Psychology; Microtubule-Associated Proteins - biosynthesis; Microtubules - physiology; Neurites - physiology; Neurons - cytology; Thyroid Hormones - deficiency; Thyroid Hormones - physiology; Tubulin - biosynthesis; Vertebrates: nervous system and sense organs; Cerebellum; Rat; Rodentia; Central nervous system; Review; Hypothyroidism; Vertebrata; Mammalia; Tubulin; Thyroid hormone; Microtubule; Differentiation; Brain (vertebrata)
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1007/BF00965840

In this review we examine successively: 1) the major effects of thyroid hormone deficiency seen during brain development with special emphasis on the changes in neuronal morphology and migration occurring postnatally in the cerebellum. 2) The effects of this hormone on microtubule assembly during neurite outgrowth and acquisition of neuronal polarity. 3) The changes in expression of the different tubulin isoforms occurring during development in the normal and hypothyroid rat brain. 4) The regulation by thyroid hormone of the transition occurring during development between the juvenile and adult microtubule-associated protein Tau.